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Update: New hope with the drug Eculizumab (Soliris) for the treatment of STEC involved HUS

5th November 2023

Following an article in the Mail Online, of 21st October 2023 in the link below about using the drug Eculizumab (Also known as Soliris) for the treatment of STEC involved HUS we contacted Professor Richard Coward who is a Professor of renal medicine at the University of Bristol and a consultant paediatric nephrologist at Bristol Royal Hospital for Sick Children. He is also one of the study’s lead authors.

https://www.dailymail.co.uk/health/article-12657795/Doctors-discover-therapy-lethal-kidney-disease-children-caused-food-poisoning.html

Professor Richard Coward’s reply was as follows:

“Our work is fundamental science and early. In it we use mouse models and human kidney cell models to show why the toxin (same one produced by E. coli O157) effects the kidney.

It is at least part due to it targeting a kidney specific cell called the podocyte and 'cellular cross-talk' with the blood vessels.

Our work shows that the complement pathway is activated and that blocking it early prevents disease.

I think what we don't know is how early this needs to be to stop the process.

I think this would be the next step (a trial with early complement inhibition) and also trying to identify ways of detecting early.

Our work also reiterated that the cellular receptor in this process is called Gb3 and this could be another way of treating (by blocking it).

I hope this is helpful”.

We appreciate this prompt reply from Professor Richard Coward. We would further like to thank all his colleagues that were involved in this work, which was funded by the Medical Research Council and Kidney Research UK.

Thank you also to all those involved with the previous Eculizumab (Soliris) drugs trial that was unfortunately cancelled during the Covid-19 pandemic in 2020.

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Update: New hope with the drug Eculizumab (Soliris) for the treatment of STEC involved HUS

5th November 2023

The Mail Online suggests new hope in treatment of Shiga toxin-producing Escherichia coli (STEC) Haemolytic Uraemic Syndrome (HUS)

23rd October 2023

According to the Mail Online article, link below, of 21st October 2023, there appears to be hope in relation to the treatment of STEC caused HUS. ... ...read on

Bureau of Investigative Journalism follow up news story shows Government failings in Salmonella outbreak.

11th September 2023

A follow up new story by the Bureau of Investigative Journalism has shown that "The UK government allowed food companies behind a major salmonella outbreak to continue supplying supermarkets even after contaminated meat had been linked to the deaths of four people... ...read on

Possible E.Coli outbreak at adventure park in Surrey

6th August 2023

It has been reported in the last week by various news outlets that Hobbledown, an adventure park close to Epson Surrey, has voluntarily closed due to a suspected outbreak of Shiga to... ...read on

News Investigation reveals source of Salmonella outbreak in the UK & antibiotic resistance.

24th June 2023

An investigation by ITN news, the Bureau of Investigative Journalism & the Guardian newspaper reveals a Salmonella outbreak in the UK and Europe in 2020-2021 was from chicken products from Poland. It also found that the chickens were given antibiotics used to trea... ...read on

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E.coli O157 & Haemolytic Uraemic Syndrome

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Update: New hope with the drug Eculizumab (Soliris) for the treatment of STEC involved HUS